- Abstracts must be written and presented in English.
- An abstract should be submitted under at least one of the abstract thematic topics list above.
- Format of the abstract:
- Title: The title should be CAPITALIZED. Please minimize the use of abbreviations in the title. Commercial trade names for drugs, devices, products, and services may NOT be used in the title.
- Authors: Names and surnames for each author must be provided. Do not include degrees or titles. Presenting authors’ names will be underlined and the corresponding author’s name will be bold.
- Affiliations: Each author should be listed by department, institution, city, and country.
- Key Word(s): A minimum of one (1) and a maximum of ten (10) keywords must be provided. Note: key words do not need to be a meeting session topic.
- Abstract body: The body of the abstract should be between 300 and 1000 words and include the following headings. Each heading is formatted in a new line with bold text, followed by a colon and space (: ). No references, tables, charts or images are allowed.
- Background: (or Introduction: )
- Objective: (or combine Background and Objective:)
- Results: (or Observations:)
- Impact on Dermatology:
- List all the related abstract thematic topics.
- Email the complete abstract along with the thematic topics to firstname.lastname@example.org.
- Abstract Submission Information:
|Abstract submission deadline||Jan. 10, 2015|
|Abstract confirmation||Jan. 31, 2015|
|Abstract submission instructions||See below|
|Email abstract submission email@example.com|
Abstract Thematic Topics:
|Ethnicity and aging||Skin biophysics and biomechanics|
|Skin surface properties||Spectroscopy|
|Skin physiology||Cross and sectional imaging|
|Cosmetic science||Dermoscopy and digital imaging|
|Clinical studies||Instruments and skin|
|Medical applications||Skin bioengineering|
|Other applications||Emerging technologies|
Abstract Submission Instructions:
POLIDOCANOL INHIBITS COWHAGE - BUT NOT HISTAMINE-INDUCED ITCH IN HUMANS - FURTHER CHARACTERIZATION OF AN EXPERIMENTAL MODEL OF HISTAMINE-INDEPENDENT ITCH
Joachim W. Fluhr, Tomasz Hawro MD, Valérie Mengeaud, PhD Daniel Redoulès, PhD , Martin K. Church PhD, DSc, Marcus Maurer MD, Martin Metz MD
Department of Dermatology and Allergy, Charité – Universitätsmedizin Berlin, Germany
Skin Research Center, Pierre Fabre Dermo Cosmetique, Toulouse, France
Key Words: itch, cowhage‐induced itch, histamine‐induced transepidermal water loss, visual analogue scale, erythema, wheal volume, flare size
Background: Histamine plays a marginal role in many pruritic conditions. Histamine‐independent itch
models are crucial for the understanding of itch pathology and testing of antipruritic agents. Cowhage spicules contain the cysteine protease, mucunain, which is released after insertion of the spicules into the skin, resulting in PAR‐2 activation and the subsequent induction of itch. Polidocanol was demonstrated to be ineffective in histamine‐induced itch.
Objectives: The study was intended to further characterize an experimental, histamine‐independent, cowhage‐induced model of pruritus and to test the antipruritic efficacy of topically applied polidocanol.
Methods: Ten healthy volunteers were challenged with histamine‐skin prick testing (SPT) and cowhage spicules. Itch was assessed by use of a visual analogue scale. Skin erythema (Mexameter), transepidermal water loss (TEWL; Tewameter TM 300)), wheal volume, and flare size were measured. Topical polidocanol treatment was tested for its efficacy on cowhage‐ and histamine‐induced itch in 45 healthy volunteers versus placebo.
Results: Polidocanol reduced cowhage‐induced itch vs. placebo (area under the curve: 149 vs. 346, p<0.05; duration: 6.3 vs. 9.9 mins., p<0.05) but not histamine‐induced itch. Skin erythema increased significantly after histamine‐SPT (204 vs. 287 arbitrary units, P<0.01) but not after cowhage. TEWL and skin temperature after skin challenges were unchanged.
Conclusion: Cowhage induces histamine‐independent itch without barrier alteration or induction of an inflammatory reaction. Polidocanol inhibits cowhage‐ but not histamine‐induced itch, indicating the importance of histamine independent itch models in the development of topical antipruritic agents.
Abstract thematic topics: Clinical studies, Skin physiology